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KMID : 0381219900220040340
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Journal of RIMSK
1990 Volume.22 No. 4 p.340 ~ p.349
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Prognostic Factors after Endocrine Therapy for Treatment of Advanced Prostatic Carcinoma
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Abstract
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We analyzed 39 patients with advanced prostatic cancer to define the results and prognostic factors after endocrine therapy. Patient ages ranged from 48 to 83 years(mean 66.0) and received immediate endocrine therapy after diagnosis. 29 patients had systemic metastasis, of whom 28 were located in bone. Majority of patients received orchiectomy. Of 32 valuable patients, 19(59.4%) showed stabilization(SD), 9(28.1%) partial response(PR), and 4 progression(PD) by objective criteria of NPCP. Mean duration of PR and SD were 34.9 months and 20.1 months, respectively. 2 and 5 year survival rate were 83.3% and 37.5%, respectively.
Number of metastatic lesion of less than 3, Gleason score of less than 8, and Karnofsky performance index of 80 or more were significant variables to predict the better response (p<0.025) and higher 2 year survival rate (p < 0.05). Age pretreatment duration, level of serum acid phosphatase, and degree of Leydig cell atrophy were not correlated with outcomes of endocrine therapy.
On conclusion, objective response to and survival after endocrine therapy in advanced prostatic cancer is limited, and only selected group of patients with intrinsically good prognosis show good results.
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